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Programa de Pós-Graduação em Ciências Aplicadas a Produtos para a Saúde – PPG-CAPS (CAPES 5)

Biomarcadores para diagnóstico laboratorial

Ementa

Ementa: Conceitos gerais. Métodos de diagnóstico tecidual. Modelos experimentais na geração de produtos aplicados em diagnóstico tecidual. Distúrbios e biomarcadores teciduais no sistema digestório. Distúrbios e biomarcadores teciduais no sistema nervoso. Distúrbios e biomarcadores no eixo intestino-cérebro. Aplicações recentes em diagnóstico e terapias. 

Referências Bibliográficas:

Conceitos gerais

1.BIOMARKERS AND RISK ASSESSMENT: CONCEPTS AND PRINCIPLES. Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization. http://apps.who.int/iris/bitstream/handle/10665/39037/9241571551-eng.pdf?sequence=1&isAllowed=y. 2.Strimbu K, Tavel JA. What are biomarkers? Curr Opin HIV AIDS. 2010 Nov;5(6):463-6. doi: 10.1097/COH.0b013e32833ed177. PMID: 20978388; PMCID: PMC3078627. 3.Vestweber D. How leukocytes cross the vascular endothelium. Nat Rev Immunol. 2015 Nov;15(11):692-704. doi: 10.1038/nri3908. Epub 2015 Oct 16. PMID: 26471775. 4.Oshima T, Miwa H. Gastrointestinal mucosal barrier function and diseases. J

Gastroenterol. 2016 Aug;51(8):768-78. doi: 10.1007/s00535-016-1207-z. Epub 2016 Apr 5. PMID: 27048502. 5.Leite AR, Borges-Canha M, Cardoso R, Neves JS, Castro-Ferreira R, Leite-Moreira A.Novel Biomarkers for Evaluation of Endothelial Dysfunction. Angiology. 2020 May;71(5):397-410. doi: 10.1177/0003319720903586. Epub 2020 Feb 20. PMID:

32077315.

Métodos de diagnóstico tecidual

1.Nowroozpoor A, Gutterman D, Safdar B. Is microvascular dysfunction a systemic disorder with common biomarkers found in the heart, brain, and kidneys? – A scoping review. Microvasc Res. 2021 Mar;134:104123. doi: 10.1016/j.mvr.2020.104123. Epub 2020 Dec 15. PMID: 33333140. 2.Oloomi M, Moazzezy N, Bouzari S. Comparing blood versus tissue-based biomarkers expression in breast cancer patients. Heliyon. 2020 Apr 3;6(4):e03728. doi:10.1016/j.heliyon.2020.e03728. PMID: 32274439; PMCID: PMC7132155. 3.Quezada-Marín JI, Lam AK, Ochiai A, Odze RD, Washington KM, Fukayama M, Rugge M, Klimstra DS, Nagtegaal ID, Tan PH, Arends MJ, Goldblum JR, Cree IA, Salto-Tellez M. Gastrointestinal tissue-based molecular biomarkers: a practical categorisation based on the 2019 World Health Organization classification of epithelial digestive tumours. Histopathology. 2020 Sep;77(3):340-350. doi: 10.1111/his.14120. Epub 2020 Jul 4. PMID: 32320495.

Modelos experimentais na geração de produtos aplicados em diagnóstico tecidual.

1. Ore A, Akinloye OA. Oxidative Stress and Antioxidant Biomarkers in Clinical and

Experimental Models of Non-Alcoholic Fatty Liver Disease. Medicina (Kaunas). 2019

Jan 24;55(2):26. doi: 10.3390/medicina55020026. PMID: 30682878; PMCID:

PMC6410206. 2.Chatterjee S, Annaert P. Drug-induced Cholestasis: Mechanisms, Models, and Markers.2.Curr Drug Metab. 2018;19(10):808-818. doi:10.2174/1389200219666180427165035. PMID: 29708070. 3.Pérez-López L, Boronat M, Melián C, Brito-Casillas Y, Wägner AM. Animal Modelsand Renal Biomarkers of Diabetic Nephropathy. Adv Exp Med Biol. 2021;1307:521- 551. doi: 10.1007/5584_2020_527. PMID: 32329028. 4.Kumar S, Vijayan M, Bhatti JS, Reddy PH. MicroRNAs as Peripheral Biomarkers in

Aging and Age-Related Diseases. Prog Mol Biol Transl Sci. 2017;146:47-94. doi: 10.1016/bs.pmbts.2016.12.013. Epub 2017 Feb 8. PMID: 28253991.

Distúrbios e biomarcadores teciduais no sistema digestório

1.Wells JM, Brummer RJ, Derrien M, MacDonald TT, Troost F, Cani PD, Theodorou V, Dekker J, Méheust A, de Vos WM, Mercenier A, Nauta A, Garcia-Rodenas CL. Homeostasis of the gut barrier and potential biomarkers. Am J Physiol Gastrointest Liver Physiol. 2017 Mar 1;312(3):G171-G193. doi: 10.1152/ajpgi.00048.2015. Epub 2016 Dec 1. PMID: 27908847; PMCID: PMC5440615. 2.Shimura T. Novel Biomarkers of Gastrointestinal Cancer. Cancers (Basel). 2021 Mar 25;13(7):1501. doi: 10.3390/cancers13071501. PMID: 33805858; PMCID: PMC8036619. 3.Liu SP, Bian ZH, Zhao ZB, Wang J, Zhang W, Leung PSC, Li L, Lian ZX. Animal Models of Autoimmune Liver Diseases: a Comprehensive Review. Clin Rev Allergy Immunol. 2020 Apr;58(2):252-271. doi: 10.1007/s12016-020-08778-6. PMID: 32076943. 4.Oates JR, McKell MC, Moreno-Fernandez ME, Damen MSMA, Deepe GS Jr, Qualls JE, Divanovic S. Macrophage Function in the Pathogenesis of Non-alcoholic Fatty Liver Disease: The Mac Attack. Front Immunol. 2019 Dec 12;10:2893. doi: 10.3389/fimmu.2019.02893. PMID: 31921154; PMCID: PMC6922022.

Distúrbios e biomarcadores teciduais no sistema nervoso

1.Ghanavatinejad F, Fard Tabrizi ZP, Omidghaemi S, Sharifi E, Møller SG, Jami MS. Protein biomarkers of neural system. J Otol. 2019 Sep;14(3):77-88. doi: 10.1016/j.joto.2019.03.001. Epub 2019 Mar 23. PMID: 31467504; PMCID: PMC6712353. 2. DeKosky ST, Kochanek PM, Valadka AB, Clark RSB, Chou SH, Au AK, Horvat C, JhaRM, Mannix R, Wisniewski SR, Wintermark M, Rowell SE, Welch RD, Lewis L, House S, Tanzi RE, Smith DR, Vittor AY, Denslow ND, Davis MD, Glushakova OY, Hayes RL. Blood Biomarkers for Detection of Brain Injury in COVID-19 Patients. J Neurotrauma. 2021 Jan 1;38(1):1-43. doi: 10.1089/neu.2020.7332. Epub 2020 Nov 11. PMID: 33115334; PMCID: PMC7757533. 3.National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Health Sciences Policy; Forum on Neuroscience and Nervous System Disorders. Biomarkers of Neuroinflammation: Proceedings of a Workshop. Washington (DC): National Academies Press (US); 2017 Sep 15. PMID: 28921942.

Distúrbios e biomarcadores no eixo intestino-cérebro

1.Butler MJ, Perrini AA, Eckel LA. The Role of the Gut Microbiome, Immunity, and Neuroinflammation in the Pathophysiology of Eating Disorders. Nutrients. 2021 Feb 3;13(2):500. doi: 10.3390/nu13020500. PMID: 33546416; PMCID: PMC7913528. 2.Garcia-Gutierrez E, Narbad A, Rodríguez JM. Autism Spectrum Disorder Associated With Gut Microbiota at Immune, Metabolomic, and Neuroactive Level. Front Neurosci. 2020 Oct 8;14:578666. doi: 10.3389/fnins.2020.578666. PMID: 33117122; PMCID: PMC7578228. 3.Grant SM, DeMorrow S. Bile Acid Signaling in Neurodegenerative and Neurological Disorders. Int J Mol Sci. 2020 Aug 20;21(17):5982. doi: 10.3390/ijms21175982. PMID: 32825239; PMCID: PMC7503576. 4.Doney E, Cadoret A, Dion-Albert L, Lebel M, Menard C. Inflammation-driven brain and gut barrier dysfunction in stress and mood disorders. Eur J Neurosci. 2021 Apr 20. doi: 10.1111/ejn.15239. Epub ahead of print. PMID: 33876886.

Aplicações recentes em diagnóstico e terapias. 

1.Frye RE, Vassall S, Kaur G, Lewis C, Karim M, Rossignol D. Emerging biomarkers in autism spectrum disorder: a systematic review. Ann Transl Med. 2019 Dec;7(23):792. doi: 10.21037/atm.2019.11.53. PMID: 32042808; PMCID: PMC6989979. 2.Yao F, Zhang K, Feng C, Gao Y, Shen L, Liu X, Ni J. Protein Biomarkers of Autism Spectrum Disorder Identified by Computational and Experimental Methods. Front Psychiatry. 2021 Feb 25;12:554621. doi: 10.3389/fpsyt.2021.554621. PMID: 33716802; PMCID: PMC7947305. 3. Hewitson L, Mathews JA, Devlin M, Schutte C, Lee J, German DC. Blood biomarker discovery for autism spectrum disorder: A proteomic analysis. PLoS One. 2021 Feb 24;16(2):e0246581. doi: 10.1371/journal.pone.0246581. PMID: 33626076; PMCID: PMC7904196.

Docente responsável: Felipe Leite